GO Enrichment Analysis One of the main uses of the GO is to perform enrichment analysis on gene sets. For example, given a set of genes that are up-regulated under certain conditions, an enrichment analysis will find which GO terms are over-represented (or under-represented) using annotations for that gene set.
Gene Ontology (GO) term enrichment is a technique for interpreting sets of genes making use of the Gene Ontology system of classification, in which genes are assigned to a set of predefined bins depending on their functional characteristics.
EnrichNet is a web-service for enrichment analysis of gene and protein lists, exploiting information from molecular networks and providing a graph …
Video created by Icahn School of Medicine at Mount Sinai for the course “Network Analysis in Systems Biology”. In the ‘Gene Set Enrichment and Network Analyses’ module the emphasis is on tools developed by the Ma’ayan Laboratory to analyze gene
Gene Set Enrichment Analysis (GSEA) is di erent from typical enrichment testing in that it takes into account the magnitude of expression di erences between conditions for each gene.
Download the GSEA software and additional resources to analyze, annotate and interpret enrichment results. Explore the Molecular Signatures Database (MSigDB) , a collection of annotated gene sets for use with GSEA software.
The original gene-set enrichment analysis (GSEA) method (Subramanian et al., 2005) was designed to analyze gene expression data, and works as follows: 1. Rank order the N genes in the dataset ( g 1 , g 2 , …, g N ) in order of their test statistic r j .
A common approach to interpreting gene expression data is gene set enrichment analysis based on the functional annotation of the differentially expressed genes (Figure 13). This is useful for finding out if the differentially expressed genes are associated with a certain biological process or molecular function.
WebGestalt (WEB-based Gene SeT AnaLysis Toolkit) is a functional enrichment analysis web tool, which has been visited 209,028 times by 84,024 unique users from 144 countries and territories since 2013 according to Google Analytics.